Quinidine {nlme} | R Documentation |
The Quinidine
data frame has 1471 rows and 14 columns.
This data frame contains the following columns:
Caucasian
,
Latin
, and
Black
identifying the race of the subject.
no
and
yes
giving smoking status at the time of the
measurement.
none
,
current
,
former
giving ethanol (alcohol) abuse status at the
time of the measurement.
No/Mild
,
Moderate
, and
Severe
indicating congestive heart failure for the subject.
< 50
< >= 50
indicating the creatine clearance (mg/min).
Verme et al. (1992) analyze routine clinical data on patients receiving the drug quinidine as a treatment for cardiac arrythmia (atrial fibrillation of ventricular arrythmias). All patients were receiving oral quinidine doses. At irregular intervals blood samples were drawn and serum concentrations of quinidine were determined. These data are analyzed in several publications, including Davidian and Giltinan (1995, section 9.3).
Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.25)
Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, Chapman and Hall, London.
Verme, C. N., Ludden, T. M., Clementi, W. A. and Harris, S. C. (1992), Pharmacokinetics of quinidine in male patients: A population analysis, Clinical Pharmacokinetics, 22, 468-480.