Phenobarbitol Kinetics

Description

The Phenobarb data frame has 744 rows and 7 columns.

Format

This data frame contains the following columns:

Subject

an ordered factor identifying the infant.

Wt

a numeric vector giving the birth weight of the infant (kg).

Apgar

an ordered factor giving the the 5-minute Apgar score for the infant. This is an indication of health of the newborn infant.

ApgarInd

a factor indicating whether the 5-minute Apgar score is < 5 or >= 5.

time

a numeric vector giving the time when the sample is drawn or drug administered (hr).

dose

a numeric vector giving the dose of drug administered (μg/kg).

conc

a numeric vector giving the phenobarbital concentration in the serum (μg/L).

Details

Data from a pharmacokinetics study of phenobarbital in neonatal infants. During the first few days of life the infants receive multiple doses of phenobarbital for prevention of seizures. At irregular intervals blood samples are drawn and serum phenobarbital concentrations are determined. The data were originally given in Grasela and Donn(1985) and are analyzed in Boeckmann, Sheiner and Beal (1994), in Davidian and Giltinan (1995), and in Littell et al. (1996).

Source

Pinheiro, J. C. and Bates, D. M. (2000), Mixed-Effects Models in S and S-PLUS, Springer, New York. (Appendix A.23)

Davidian, M. and Giltinan, D. M. (1995), Nonlinear Models for Repeated Measurement Data, Chapman and Hall, London. (section 6.6)

Grasela and Donn (1985), Neonatal population pharmacokinetics of phenobarbital derived from routine clinical data, Developmental Pharmacology and Therapeutics, 8, 374-383.

Boeckmann, A. J., Sheiner, L. B., and Beal, S. L. (1994), NONMEM Users Guide: Part V, University of California, San Francisco.

Littell, R. C., Milliken, G. A., Stroup, W. W. and Wolfinger, R. D. (1996), SAS System for Mixed Models, SAS Institute, Cary, NC.