Dose Response Data Set

Description

Dose response study of an angina drug; data set taken from Westfall et al. (1999, p. 164). Different trend tests in a balanced one-way layout.

Usage

data(angina)

Format

This data frame contains the following variables

dose

Treatments at 5 levels: 0, 1, 2, 3, 4

response

Response variable: change from pretreatment as measured in minutes of pain-free walking.

Details

See Westfall et al. (1999, p. 164)

Source

P. H. Westfall, R. D. Tobias, D. Rom, R. D. Wolfinger, Y. Hochberg (1999). Multiple Comparisons and Multiple Tests Using the SAS System. Cary, NC: SAS Institute Inc.

Examples

data(angina)

# perform a dose-response analysis using simultaneous confidence 
# intervals for Williams' contrasts
summary(ci <- simint(response~dose, data=angina, alternative="greater",
               type="Williams"))
plot(ci, cex.axis=1.75, lwd=1.5)

# consider the same data set as a changepoint problem
summary(simint(response~dose, data=angina, alternative="greater",
               type="Changepoint"))

# compute now adjusted p-values for McDermott's test on trend
summary(simtest(response~dose, data=angina, type="McDermott",
                alternative="greater",ttype="logical"))