Remission Times for Acute Myelogenous Leukaemia

Description

The aml data frame has 23 rows and 3 columns.

A clinical trial to evaluate the efficacy of maintenance chemotherapy for acute myelogenous leukaemia was conducted by Embury et al. (1977) at Stanford University. After reaching a stage of remission through treatment by chemotherapy, patients were randomized into two groups. The first group received maintenance chemotherapy and the second group did not. The aim of the study was to see if maintenance chemotherapy increased the length of the remission. The data here formed a preliminary analysis which was conducted in October 1974.

Usage

aml

Format

This data frame contains the following columns:

time

The length of the complete remission (in weeks).

cens

An indicator of right censoring. 1 indicates that the patient had a relapse and so time is the length of the remission. 0 indicates that the patient had left the study or was still in remission in October 1974, that is the length of remission is right-censored.

group

The group into which the patient was randomized. Group 1 received maintenance chemotherapy, group 2 did not.

Note

Package survival also has a dataset aml. It is the same data with different names and with group replaced by a factor x.

Source

The data were obtained from

Miller, R.G. (1981) Survival Analysis. John Wiley.

References

Davison, A.C. and Hinkley, D.V. (1997) Bootstrap Methods and Their Application. Cambridge University Press.

Embury, S.H, Elias, L., Heller, P.H., Hood, C.E., Greenberg, P.L. and Schrier, S.L. (1977) Remission maintenance therapy in acute myelogenous leukaemia. Western Journal of Medicine, 126, 267-272.